Deadly shadow: Measles may weaken immune system up to 3 years -- ScienceDaily

Deadly shadow: Measles may weaken immune system up to 3 years -- ScienceDaily

Published in the journal Science, the study, led by researchers from Princeton University's Woodrow Wilson School of Public and International Affairs and Department of Ecology and Evolutionary Biology, provides epidemiologic evidence that measles may throw the body into a much longer-term state of "immune amnesia," where essential memory cells that protect the body against infectious diseases are partially wiped out.

"We already knew that measles attacks immune memory, and that it was immunosuppressive for a short amount of time. But this paper suggests that immune suppression lasts much longer than previously suspected," said C. Jessica Metcalf, co-author and assistant professor of ecology and evolutionary biology and public affairs at Princeton. "In other words, if you get measles, three years down the road, you could die from something that you would not die from had you not been infected with measles."

"Our findings suggest that measles vaccines have benefits that extend beyond just protecting against measles itself," said lead author Michael Mina, a medical student at Emory University who worked on the study as a postdoctoral researcher at Princeton." It is one of the most cost-effective interventions for global health."

Mina was motivated to pursue this analysis after reading a paper co-authored by Rik L. de Swart from Erasmus University Medical Center in the Netherlands, which found profound associations between measles and memory-cell depletion. This research demonstrated that the measles virus attacks T lymphocytes -- cells that build up "immune memory" against other diseases -- creating a state of immune amnesia. After about a month, these immune memory cells return, but instead of protecting against previously encountered infections, they were almost entirely directed against measles alone.

Mina wondered how quickly the immune system would become broadly protective again and went on to examine detailed population data available from the United States, England and Wales, and Denmark -- the only countries with the key variables required for the analysis. In addition to Metcalf and de Swart, Mina worked with Bryan Grenfell, Kathryn Briger and Sarah Fenton Professor of Ecology and Evolutionary Biology and Public Affairs at Princeton, and Albert Osterhaus, professor of virology at Eramus University. Together, the research team hypothesized that if immune amnesia does occur because of measles, it would be evident in population data.

The researchers looked at deaths among children between the ages of 1 and 9 in Europe, and 1 and 14 in the United States, in both pre- and post-vaccine eras. They ran a basic association test -- comparing measles incidence and deaths. The initial analysis came back statistically significant but weaker than expected, not showing a strong connection between the two.

At this point, Mina and his collaborators decided to evaluate the data making different assumptions about how long the possible immune-amnesia effects of measles may last. This exploration uncovered a very strong correlation between measles incidence and deaths from other diseases, allowing for a "lag period" averaging roughly 28 months after infection with measles. This finding was consistent in all age groups across the three countries and also consistent in pre- and post-vaccine eras.

"In other words, reducing measles incidence appears to cause a drop in deaths from other infectious diseases due to indirect effects of measles infection on the human immune system," Grenfell said. "At the population level, the data suggests that when measles was rampant, it may have led to a reduction in herd immunity against other infectious diseases."

With regard to policy, the research findings suggest that -- apart from the major direct benefits -- measles vaccination may also provide indirect immunological protection against other infectious diseases. Mina and his collaborators hope the paper will spur future research.

"The real smoking gun would be to carry out cohort studies, as well as to explore the immunological mechanisms underlying the responses we see," Grenfell said.

"We also intend to analyze the long-term impact of 'immunological amnesia' on morbidity or sickness, especially since measles currently causes very few deaths in developed countries," Mina said. "And we need to explore consequences for resource-poor countries, where measles causes much more immediate mortality."

Welcome to SUV System Ltd!

SUV System Ltd is ISO 90012008 Certified electronics distributor with 10 years of experiences.

We have built up long term business relationship with about many companies which are stockers and authorized agents. we have a steady and reliable supply to meet customer's demands to the greatest extent .Confidently, we are able to lower your cost and support your business with our years of professional service.

SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com

Electronic Components distributor:http://www.suvsystem.com

Connectors Distributor:http://www.suvsystem.com/l/Connectors-1.html

IC Distributor:http://www.suvsystem.com/l/IC(Integrated-Circuits)-1.html

LED Distributor:http://www.suvsystem.com/l/LED-1.html

Capacitor Distributor:http://www.suvsystem.com/l/Capacitor-1.html

Transistor Distributor:http://www.suvsystem.com/l/Transistors-1.html

Resistor Distributor:http://www.suvsystem.com/l/Resistors-1.html

Diode Distributor:http://www.suvsystem.com/l/Diodes-1.html

SUV System Ltd insists on the managing faith ofsincereness,speciality,foresight, win-win,so we build up stable-relationship customers located all over the world, including the States, Europe, Argentina, UAE, Malaysia, Australia,and India etc

we are focus on the following fields,and hope we can help you.

INFLNEON Diodes TI IC components Current Sensors Resistors Military IC IR transistor Kingbrigt LED ELPIDA IC YAGEO Resistors Ligitek LED HARRIS IC Civil IC Discrete Semiconductor Transistors MOTOROLA IC ROHM Resistors Cypress IC Industrial IC Rectifier Diodes DIODES Transistors Chip Inductors AVX Resistors Xilinx IC LED Low Ohmic Resistors Thick Film Resistors PANASONIC Resistors Electronic News ST Transistors NXP Transistors NEC Transistors Switching Diodes Transistors Freescale Other Parts Switches Bipolar Transistors MAXIM IC Dialight LED TOSHIBA Transistors Transistors ALTERA IC
http://www.suvsystem.com/a/45786.aspx